Sponsored Content
Newly published results on Unigen's Symetrian™ for rapid immune activation
18 Sep 2023
Significant clinical study results quantifying rapid immune activation after one dose of UP360 (Symetrian) have been published by NIS Labs in collaboration with Unigen, Inc. UP360 is marketed under Unigen’s brand name Symetrian™. NIS Labs is a contract research organization (CRO) providing clinical studies and lab assays that help clients support efficacy claims and differentiate their products from competition.
UP360 is an Aloe-based nutraceutical composition formulated for healthy immune homeostasis. The composition also contains extracts from the Poria cocos mushroom and from rosemary. This is the first study to document the rapid immune activation that happens after consuming a single dose of UP360. The randomized, double-blind, placebo-controlled, cross-over clinical trial involving supplementation with UP360 provides evidence for a rapid mobilization of immune cells, specifically those cells that are involved in the immediate (“innate”) immune protection when encountering a pathogen.
“The UP360 nutraceutical formulation was studied using our unique and highly controlled study design for evaluating changes within the immune system within hours of consuming a single dose of a natural product,” says Dr. Gitte Jensen, founder and research director at NIS Labs. “Highly significant changes in immune activation and surveillance activity were documented starting at 1 hour, with downstream effects seen at 2 and 3 hours. These changes are rapid and transient, as the immune system returns to homeostasis.”
The results were published in PLoS One, “Rapid increase in immune surveillance and expression of NKT and γδT cell activation markers after consuming a nutraceutical supplement containing Aloe vera gel, extracts of Poria cocos and rosemary. A randomized placebo-controlled cross-over trial.” The trial involved 11 healthy participants, consuming UP360 on one clinic visit and placebo on the other clinic visit. On each visit, a period of rest was followed by a baseline blood draw and consuming a test product. Additional blood draws were performed at 1, 2, and 3 hours after consuming a product. The results showed rapid increases immune surveillance and alertness, increased levels of chemokines and the stem cell-mobilizing growth factor G-CSF, and increased enzymatic activity for the body’s own antioxidant enzymes superoxide dismutase and catalase.
Unigen Chief Scientific Officer, Dr. Qi Jia, stated, “This study is pivotal in documenting that a single dose of UP360 supports and activates the natural defense of the immune system in protecting our body. The waves of immune activation through cytokine releases, in combination with the waves of immune cell migration, suggests a highly coordinated sequence of events after consuming UP360.” Dr. Jia explained that the initial wave is associated with release of chemokines, followed by immune cell activation. The third wave involves highly significant migration of natural killer cells, CD8+ T cells and γδ T cells, parts of our innate immune defense system. “Because we applied a study design that is able to capture these rapid events, we were able to demonstrate this unique effect of consuming UP360.”
Related news
Roquette at Fi Europe: Empowering people and planet via plant-based innovation [Interview]
26 Jan 2024
Presenting its latest F&B solutions under the banner of ‘Empowering healthier and more sustainable food choices’, Roquette’s appearance at the most recent edition of Fi Europe coincided with the innovative company’s 90th anniversary.
Read moreEmsland at Fi Europe 2023: Leading the field in sustainability and future-proofed food [Interview]
26 Jan 2024
Germany-headquartered Emsland is a vegetable protein and fibre pioneer responding in earnest to the food sector’s sustainability challenge, while supporting its customers to develop plant-based, clean label and nutritionally enhanced products through “...
Read moreStand out from the shelf and put Health First with Prebiotic Chicory Root Fibres
22 Jan 2024
If you are looking to differentiate from all other products on the market, then innovating with proven prebiotics should be your next New Product Development. When it comes to food and drink choices, consumers often take into consideration a manif...
Read moreSYNBALANCE ANNOUNCES ITS FIRST CAPSULE COLLECTION FOR INCLUSING HEALTH
20 Dec 2023
SynBalance, the biotics-oriented company, focused on delivering highly scientifically evidenced probiotic solutions, is proud to present THE ART OF WELL-BEING capsule collection.
Read more
Bioriginal expands the business in The Netherlands and Japan
13 Dec 2023
Bioriginal Food & Science Corp has completed two significant acquisitions that will expand the company’s global footprint in the EU and Asia.
Read moreBioriginal expands in Germany acquiring plant-based oil products company
13 Dec 2023
Bioriginal has expanded into Germany with the acquisition of Pflanzenölmühle Kroppenstedt GmbH operating as Kroppenstedter Ölmühle, a century-old, family-owned mill that specializes in the pressing of plant-based oil products from c...
Read moreBioriginal Acquires Softgel Co. To Expand Nutrition Products
13 Dec 2023
Bioriginal has expanded further into the United States with the acquisition of all the operating assets of Softgel Co. ("Softgel"), including a state-of-the-art softgel, squeeze tube and tincture manufacturing facility that specializes in enc...
Read moreACT Expands Global Presence: New Sales Office in Spain in Febuary 2024
13 Dec 2023
ACT proudly announces the inauguration of a new sales office in Spain as of 1st of February 2024. This strategic expansion marks a significant milestone in the company's global growth initiative, aiming to strengthen its foothold in the European ma...
Read moreBunge’s Beleaf™ PlantBetter: Elevating Plant-Based Alternatives to Match Dairy Butter - A breakthrough for taste, texture, and versatility on par with dairy butter
12 Dec 2023
Zaandam, The Netherlands, 20 November 2023 – Bunge, a global leader in food and agribusiness, introduces Beleaf™ PlantBetter, a ground-breaking plant-based alternative crafted to satisfy the growing demand for superior-tasting and environme...
Read moreofi's Carbon Scenario Planner wins prestigious Food Ingredients Europe Award
12 Dec 2023
ofi’s Carbon Scenario Planner (CSP), a new digital tool developed to help food and beverage manufacturers model the impact of different scenarios for reducing greenhouse gas emissions has won the 2023 Sustainability Innovation Award at Food Ingre...
Read more